Journal Articles
RELISTOR®
(methylnaltrexone bromide) 8 mg/12 mg subcutaneous injection
Subcutaneous injection
2024
Safe management of adverse effects associated with prescription opioids in the palliative care population: a narrative review
Zimmerman A, et al. J Clin Med. 2024
2023
Impact of patient subgroups on the efficacy and safety of methylnaltrexone for opioid-induced constipation in patients with advanced illness
Mehta N, et al. J Pain Res. 2023
Response rates to methylnaltrexone in hospitalized cancer patients
Harris D, et al. Am J Hosp Palliat Care. 2023
Management of constipation in hospitalized patients
Sayuk GS, et al. J Clin Med. 2023
Methylnaltrexone treatment for opioid-induced constipation in patients with and without cancer: effect of initial dose
Chamberlain BH, et al. J Pain Res. 2023
Methylnaltrexone for opioid induced dysmotility in critically ill infants and children: a pilot study
Smith CJ, et al. J Pediatr Pharmacol Ther. 2023
Reductions in all-cause mortality associated with the use of methylnaltrexone for opioid-induced bowel disorders: a pooled analysis
Webster LR, et al. Pain Med. 2023
Subcutaneous methylnaltrexone as treatment for opioid-induced constipation in patients with advanced cancer and noncancer illnesses: a post hoc analysis of two clinical trials
Shah ED, et al. J Pain Res. 2023
Cumulative laxation response with methylnaltrexone: implications for hospitalized patients with advanced illness and opioid-induced constipation
Farchadi D, et al. Curr Ther Res Clin Exp. 2023
2022
First-dose efficacy of methylnaltrexone in patients with severe medical illness and opioid-induced constipation: a pooled analysis
Peacock WF, et al. Journal of Emergency Medicine. 2022.
2021
Attrition of methylnaltrexone treatment-emergent adverse events in patients with chronic noncancer pain and opioid-induced constipation: a post hoc pooled analysis of two clinical trials
Mehta N, et al. F1000 Research. 2021.
Efficacy and safety of peripherally acting μ-opioid receptor antagonist (PAMORAs) for the management of patients with opioid-induced constipation: a systematic review
Rekatsina M, et al. Cureus. 2021.
The influence of age on central effects of methylnaltrexone in patients with opioid-induced constipation
Liao SS, et al. Drugs & Aging. 2021.
2020
Management of opioid-induced and non-opioid-related constipation in patients with cancer: systematic review and meta-analysis
Ginex PK, et al. Oncology Nursing Forum. 2020.
Efficacy and safety of peripherally acting mu-opioid receptor antagonists for the treatment of opioid-induced constipation: a Bayesian network meta-analysis
Ouyang R, et al. Pain Medicine. 2020.
Systematic review with meta-analysis: efficacy and safety of treatments for opioid-induced constipation
Vijayvargiya P, et al. Alimentary Pharmacology and Therapeutics. 2020.
Methylnaltrexone for the treatment of opioid-induced constipation and gastrointestinal stasis in intensive care patients. Results from the MOTION trial
Patel PB, et al. Intensive Care Medicine. 2020.
Subcutaneous methylnaltrexone for opioid-induced constipation in advanced-illness patients with or without active cancer
Chamberlain BH, et al. Pain Management. 2020.
2019
Identifying and treating opioid side effects: the development of methylnaltrexone
Moss J. Anesthesiology. 2019.
Pharmacological treatment of opioid-induced constipation is effective but choice of endpoints affects the therapeutic gain
Nusrat S, et al. Digestive Diseases and Sciences. 2019.
2018
Efficacy of treatments for opioid-induced constipation: systematic review and meta-analysis
Nee J, et al. Clinical Gastroenterology and Hepatology. 2018.
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care
Candy B, et al. Cochrane Database of Systematic Reviews. 2018.
Drugs for treating opioid-induced constipation: a mixed treatment comparison network meta-analysis of randomized controlled clinical trials
Sridharan K, et al. Journal of Pain and Symptom Management. 2018.
2017
Long-term safety and efficacy of subcutaneous methylnaltrexone in patients with opioid-induced constipation and chronic noncancer pain: a phase 3, open-label trial
Webster LR, et al. Pain Medicine. 2017.
Phase II trial of subcutaneous methylnaltrexone in the treatment of severe opioid-induced constipation (OIC) in cancer patients: an exploratory study
Mori M, et al. International Journal of Clinical Oncology. 2017.
2016
Protocol for a randomised control trial of methylnaltrexone for the treatment of opioid-induced constipation and gastrointestinal stasis in intensive care patients (MOTION)
Patel PB, et al. BMJ Open. 2016.
Efficacy and safety of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain: a placebo crossover analysis
Viscusi ER, et al. Regional Anesthesia & Pain Medicine. 2016.
Efficacy of methylnaltrexone for the treatment of opioid-induced constipation: a meta-analysis and systematic review
Mehta N, et al. Postgraduate Medicine. 2016.
2015
Efficacy and tolerability of subcutaneous methylnaltrexone in patients with advanced illness and opioid-induced constipation: a responder analysis of 2 randomized, placebo-controlled trials
Nalamachu SR, et al. Pain Practice. 2015.
Advances in pharmacotherapy for opioid-induced constipation - a systematic review
Siemens W, et al. Expert Opinion on Pharmacotherapy. 2015.
2013
Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysis
Ford AC, et al. The American Journal of Gastroenterology. 2013.
2012
Subcutaneous methylnaltrexone for treatment of acute opioid-induced constipation: phase 2 study in rehabilitation after orthopedic surgery
Anissian L, et al. Journal of Hospital Medicine. 2012.
2011
Characterization of abdominal pain during methylnaltrexone treatment of opioid-induced constipation in advanced illness: a post hoc analysis of two clinical trials
Slatkin NE, et al. Journal of Pain Symptom Management. 2011.
Efficacy of subcutaneous methylnaltrexone in the treatment of opioid-induced constipation: a responder post hoc analysis
Michna E, et al. Pain Medicine. 2011.
Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study
Michna E, et al. Journal of Pain. 2011.
Laxatives or methylnaltrexone for the management of constipation in palliative care patients
Candy B, et al. Cochrane Database of Systematic Reviews. 2011.
Effect of subcutaneous methylnaltrexone on patient-reported constipation symptoms
Iyer SS, et al. Value in Health. 2011.
Methylnaltrexone for opioid-induced constipation in patients with advanced illness: a 3-month open-label treatment extension study
Lipman AG, et al. Journal of Pain & Palliative Care Pharmacotherapy. 2011.
2009
Methylnaltrexone treatment of opioid-induced constipation in patients with advanced illness
Chamberlain BH, et al. Journal of Pain and Symptom Management. 2009.
Methylnaltrexone for treatment of opioid-induced constipation in advanced illness patients
Slatkin NE, et al. Journal of Supportive Oncology. 2009.
2008
Efficacy and safety of mu-opioid antagonists in the treatment of opioid-induced bowel dysfunction: systematic review and meta-analysis of randomized controlled trials
McNicol ED, et al. Pain Medicine. 2008.
Subcutaneous methylnaltrexone for the treatment of opioid-induced constipation in patients with advanced illness: a double-blind, randomized, parallel group, dose-ranging study
Portenoy RK, et al. Journal of Pain Symptom Management. 2008.
Methylnaltrexone for opioid-induced constipation in advanced illness
Thomas J, et al. New England Journal of Medicine. 2008.
Mu-opioid antagonists for opioid-induced bowel dysfunction
McNicol ED, et al. Cochrane Database of Systematic Reviews. 2008.
2007
Peripherally acting opioid antagonists in the treatment of opiate-related constipation: a systematic review
Becker G, et al. Journal of Pain and Symptom Management. 2007.
2002
Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial
Yuan CS, et al. Journal of Pharmacology & Experimental Therapeutics. 2002.