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Learn more about the therapeutic areas for which Salix is engaged in clinical research.
Disorders of gut-brain interaction (DGBIs), a group of conditions formerly known as functional gastrointestinal (GI) disorders,1-3 are associated with any combination of motility disturbances, such as visceral hypersensitivity, alterations in mucosal and immune function, gut microbiome dysbiosis, and altered central and peripheral nervous system processing.3 Two of the most common DGBIs are irritable bowel syndrome (IBS), which is further categorized into subtypes (ie, diarrhea-predominant IBS [IBS-D]; constipation-predominant IBS [IBS-C]; IBS with mixed bowel habits [IBS-M]; and IBS unclassified [IBS-U]), and functional constipation, at times referred to as chronic idiopathic constipation (CIC).3-6
Opioid-induced constipation (OIC) refers to a spectrum of disorders that develop secondary to the actions of opioid analgesics on the GI tract and the central nervous system.6 OIC is symptomatically similar to CIC but is characterized by new or worsening symptoms when initiating, changing, or increasing opioid therapy.4
Hepatic encephalopathy (HE) is a frequent complication of cirrhosis. It is defined as a brain dysfunction caused by liver insufficiency and/or portosystemic shunting that manifests as a wide spectrum of neurological or psychiatric abnormalities, ranging from subclinical alterations to coma. HE that manifests clinically is classified as overt HE, which represents the decompensated phase of cirrhosis and is typically recurrent or persistent.7
Travelers’ diarrhea (TD) refers to the development of unformed stools among individuals from resource-rich areas of the world during travel or within 10 days of returning from resource-limited areas of the world.8 TD affects an estimated 40% to 60% of travelers and is the most common travel-associated condition.9 Dehydration is the primary complication of TD, although severe dehydration may lead to other more serious complications.8,9
Colonoscopy is one of the most important preventative care measures for reducing the risk of colon cancer and is used widely for diagnostic evaluation of symptoms and other screening tests.10 Bowel preparation (cleansing) is necessary for direct visualization of the colonic mucosa for analysis and polyp removal during colonoscopy.11 As many as 20% to 25% of all colonoscopies are reported to have an inadequate bowel preparation.10
View product- and therapeutic area–related publications appearing in peer-reviewed journals.
References
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Sayuk GS. Insights on disorders of gut-brain interaction. In: Chey WD, ed. Advances in IBS: Current developments in the treatment of irritable bowel syndrome. .
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Singh R, Zogg H, Ghoshal UC, Ro S. Current treatment options and therapeutic insights for gastrointestinal dysmotility and functional gastrointestinal disorders. .
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Sperber AD, Bangdiwala SI, Drossman DA, et al. Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation global study. .
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Camilleri M, Ford AC, Mawe GM, et al. Chronic constipation. .
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Sharma A, Rao SSC, Kearns K, Orleck KD, Waldman SA. Review article: diagnosis, management and patient perspectives of the spectrum of constipation disorders. .
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Lacy BE, Mearin F, Chang L, et al. Bowel disorders. .
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Vilstrup H, Amodio P, Bajaj J, et al. Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. .
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LaRocque R, Harris JB. Travelers’ diarrhea: epidemiology, microbiology, clinical manifestations, and diagnosis. September 6, 2022. Accessed November 7, 2022. https://www.uptodate.com/contents/travelers-diarrhea-epidemiology-microbiology-clinical-manifestations-and-diagnosis
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Dunn N, Okafor CN. Travelers Diarrhea. Treasure Island, FL: .
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Johnson DA, Barkun AN, Cohen LB, et al. Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US Multi-Society Task Force on Colorectal Cancer. .
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Kastenberg D, Bertiger G, Brogadir S. Bowel preparation quality scales for colonoscopy. .
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